Artifact-Free High-Resolution Myocardial Perfusion MRI in Subjects With Abnormal Nuclear Myocardial Perfusion Studies
Completed · Not applicable
Conditions studied: Coronary Artery Disease, CAD
In brief
This is a pilot study in a patient population with suspected coronary artery disease (CAD) as defined by the presence of a prior abnormal nuclear (PET/SPECT) myocardial perfusion scan. In this study design, PET/SPECT will serve as the comparative standard for presence of myocardial ischemia. We intend to determine the accuracy of an improved magnetic resonance imaging (MRI) technique for detection of myocardial ischemia in subjects with suspected CAD. This is not a study to specifically evaluate the efficacy or safety of the drugs but rather the diagnostic performance of the improved cardiac MRI procedure.
Key facts
- Study ID
- NCT01949844
- Run by
- Daniel S. Berman
- People needed
- 44
- Starts
- 2014-05-16
- Expected to finish
- 2017-10-23
- Last updated by the study team
- 2018-08-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Clinically indicated nuclear myocardial perfusion (PET/SPECT) study with mild to moderate ischemia or prior myocardial infarction AND a visual scan interpretation of definitely abnormal AND no intervening revascularization since the prior study; or,
- Clinically stable individuals with suspected or known coronary artery disease on the basis of coronary angiography.
You may not qualify if…
- < 18 years of age
- Hypotension (systolic blood pressure <100 mm Hg)
- Significant non-coronary cardiac disease (e.g. severe valvular abnormality, significant cardiomyopathy, etc.)
- Persons unable to successfully pass MRI health and safety screening
- Persons whose renal function test does not meet CSMC standard of care MRI contrast protocol requirements (GFR <45 ml/min based on serum creatinine, age, gender, and ethnicity).
- Subjects with contraindications to or intolerance of regadenoson.
- Persons with an allergy to gadolinium-based contrast.
- Persons with a history of kidney or liver disease.
Where it is running
- Cedars-Sinai Medical Center — Los Angeles, California, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.