Fecal Microbiota Transplantation (FMT) for Treatment of Ulcerative Colitis in Children

Completed · Phase 1

Conditions studied: Ulcerative Colitis

In brief

Patients diagnosed with ulcerative colitis (UC), a specific type of inflammatory bowel disease, will be invited to take part in this study. The investigators do not know what causes UC. However, the microbes (such as bacteria and viruses), which normally live in our intestines are thought to play an important role in the development of UC. There are many treatment options for UC such as steroids,and other medications that decrease inflammation. However, none of these can cure the disease. This study aims to treat pediatric UC in an alternative fashion by changing the microbes in the gut by giving the participant's stool specimens from healthy adult individuals. There is some evidence from a few cases of adult UC that this therapy may cure the disease or at least provide long lasting suppression (remission) of the symptoms. The investigators would like to test this therapeutic intervention in children with UC. The purpose of this study is to (1) examine the microbiome of stool and colon (2) and to determine whether healthy-donated stool enemas can treat pediatric ulcerative colitis. (3) The investigators will also study the effects of the treatment on colonic gene expression.

Key facts

Study ID
NCT01947101
Run by
Baylor College of Medicine
People needed
6
Starts
2014-02-01
Expected to finish
2016-05-01
Last updated by the study team
2016-06-14

Who can join

Age: 12 and older, up to 20. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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