Nebulized Hypertonic Saline for Mechanically Ventilated Children

Completed · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Respiratory Failure

In brief

Children who need to be on a ventilator often have thick secretions/mucus in their lungs. These secretions can obstruct the breathing tube and their windpipe, which can worsen lung function and prolong the need for the ventilator. Hypertonic saline is a medicine that is used to thin out secretions in patients with cystic fibrosis (and other conditions). We hypothesize that having children on a ventilator inhale this medication will shorten the amount of time that they need to be on the ventilator.

Key facts

Study ID

NCT01945944

Run by

University Hospitals Cleveland Medical Center

People needed

18

Starts

2013-10-01

Expected to finish

2014-05-01

Last updated by the study team

2016-06-28

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• invasive mechanical ventilation of < 12 hrs duration prior to enrollment
• expected duration of mechanical ventilation of > 48hrs from enrollment
• age < 18yo

You may not qualify if…

• inclusion in another clinical study
• cystic fibrosis
• status asthmaticus
• pulmonary hemorrhage/contusion
• home O2 use
• home non-invasive positive pressure (CPAP/BiPAP) ventilation use
• pre-existing tracheostomy
• prescription of mucolytic medication by primary clinical team
• allergy to inhaled saline/hypertonic saline or albuterol

Where it is running

• Rainbow Babies and Children's Hospital (of Univ. Hospitals Case Med. Center) — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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