Magnetic Resonance Imaging (MRI) in Amyotrophic Lateral Sclerosis (ALS)
Withdrawn before enrolling · Not applicable
Conditions studied: Amyotrophic Lateral Sclerosis (ALS)
In brief
This is a pilot study to identify the degree of grey and white matter involvement in patients with Amyotrophic Lateral Sclerosis (ALS) utilizing non-invasive techniques. The imaging to be utilized will be the 7 Tesla (7T) magnetic resonance imaging (MRI) of the brain. These results will be correlated to the ALS Functional Rating Scale - Revised (ALSFRS-R) score to assess if any changes in MRI can be predictive in the disability of the ALS patients at baseline and at 6 month intervals. The participants will be asked to return every 6 months for a neurological examination, ALSFRS-R assessment, measurement of the vital capacity and MRI as outlined above to monitor progression of the disease.
Key facts
- Study ID
- NCT01945853
- Run by
- Johns Hopkins University
- People needed
- 0
- Starts
- 2013-07-01
- Expected to finish
- 2015-04-01
- Last updated by the study team
- 2015-09-01
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Males and Females who are 18 - 80 years old.
- The participants will meet the standard diagnostic criteria for possible or probable ALS (based on El Escorial criteria). They will have been diagnosed by a Johns Hopkins Neurologist.
- Healthy controls will be recruited by their interest in assisting the ALS population.
You may not qualify if…
- Forced vital capacity less than 60 % of predicted value.
- Documented orthopnea on ALSFRS-R or otherwise unable to lie flat in an MRI scanner for the duration of the study.
- Presence of pacemakers, aneurysm clips, shrapnel or otherwise disallowed implanted metallic devices for obtaining an MRI scan.
- Pregnant or lactating females
- Glomerular filtration rate (GFR) less than 60
- History of: encephalitis, extensive white matter disease, intracranial hemorrhage, cerebral palsy, allergy to dye and/or IV drug abuse.
Where it is running
- Johns Hopkins University — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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