International Ataxia Rating Scale in Younger Patients

Completed

Conditions studied: Ataxia Telangiectasia

In brief

The project will collect information on the mapping of clinical ratings on a number of scales that are used in the assessment of patients with ataxias.

Key facts

Study ID

NCT01942850

Run by

Quince Therapeutics S.p.A.

People needed

63

Starts

2013-08-01

Expected to finish

2014-05-01

Last updated by the study team

2014-12-31

Who can join

Age: 6 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 6-18 years with diagnosed with ataxia, preferably AT will be included. The diagnosis of AT will be made based on the criteria: typical clinical picture plus one of the following: 1. a proven mutation in the ATM gene 2. Deficient ATM protein proven by Western blotting 3. Elevated α-fetoprotein, cerebellar atrophy on MRI and immune deficiency/ chromosomal breakage/ T- cell lymphoreticular malignancy.
• Children aged 6-18 years with suspected AT (fulfilling partially the above criteria will be included)
• Children aged 6-18 years with AT like disease, with or without proven mutation in the MRE11 gene will be included
• Children aged 6-18 years of age with ataxia of other known or unknown etiologies might be included, but their total number should not exceed 20% of the cohort in each site

Where it is running

• Carol Morsani USF Health Center — Tampa, Florida, United States
• Jaslok Hospital — Mumbai, India
• Edmond and Lilly Safra Childrens Hospital Pediatric Unit — Tel Litwinsky, Israel
• Università La Sapienza — Roma, Italy, Italy
• A.O Spedalli Civilli Brescia — Brescia, Italy

Full record on ClinicalTrials.gov

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