A Comparison of Medication Augmentation and PST in the Treatment of Depression in Older Adults

Withdrawn before enrolling · Phase 4

Conditions studied: Major Depressive Disorder, Dysthymic Disorder, Depressive Disorder Not Otherwise Specified (NOS)

In brief

The purpose of this study is to compare the effectiveness of two different augmentation strategies of antidepressant treatment for depressed older adults who have not responded to an adequate trial of antidepressant medication. The first augmentation strategy is Problem Solving Therapy (PST), a 12-week psychotherapy treatment that has been shown to be effective in depressed older adults. The second augmentation strategy is medication augmentation, which will begin with six weeks of aripiprazole, an atypical antipsychotic medication that has also been shown to be effective in depressed older adults who have failed a trial of antidepressant medication.

Key facts

Study ID

NCT01942187

Run by

New York State Psychiatric Institute

People needed

0

Starts

2013-08-01

Expected to finish

2015-12-01

Last updated by the study team

2019-04-18

Who can join

Age: 50 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages 50-90, inclusive
• Current diagnosis of major depressive disorder or dysthymia
• Treatment with either citalopram 30/mg or duloxetine 60 mg/day (6 weeks total, with at least three weeks of treatment at that dose)
• Hamilton Rating Scale for Depression (HRSD) >= 14
• Willing and able to complete NP testing
• Willing and able to complete medical exam, EKG, blood tests, and urine screen
• Willing and able to give consent

You may not qualify if…

• Meets criteria for psychotic depression
• MMSE score <24
• Bipolar disorder, psychotic disorder, or OCD
• History of alcohol or drug dependence (excluding nicotine) within past six months
• Suicide attempt within past six months or HRSD item 2 score > 2
• Diagnosis of probable Alzheimer's disease
• Diagnosis of probable vascular dementia
• Acute, severe, or unstable medical illness
• Patients in psychotherapy
• Diagnosis of Parkinson's Disease
• Blood glucose >200 and/or total cholesterol >250

Where it is running

• New York State Psychiatric Institute — New York, New York, United States

Full record on ClinicalTrials.gov

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