Androgen Regulation of Priapism in Sickle Cell Disease

Withdrawn before enrolling · Early Phase 1

Conditions studied: Priapism, Sickle Cell Disease, Hypogonadism

In brief

It is believed that when androgen (testosterone) levels are below normal there is a disturbance of normal bodily functioning that is associated with priapism in some men. Conversely, it is believed that testosterone replacement will improve the condition of priapism when the testosterone levels are brought to normal. In turn, this will also improve psychological well being in men with sickle cell disease (SCD).

Key facts

Study ID

NCT01940718

Run by

Johns Hopkins University

People needed

0

Starts

2014-03-01

Expected to finish

2016-01-01

Last updated by the study team

2017-01-19

Who can join

Age: 18 and older, up to 50. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Ages 18-50
• History of SCD
• Episodes of prolonged penile erection in the absence of sexual interest or desire, with an average frequency of at least twice weekly, when averaged over the previous four weeks
• serum testosterone level below 550 ng/dl
• Ability to provide informed consent

You may not qualify if…

• Alcohol use exceeding two standard drinks daily
• Prostate conditions including prostate specific antigen (PSA) elevation (>2.5 ng/ml)
• Known sleep apnea
• Known cirrhosis
• Enlarged and painful male breasts

Where it is running

• Johns Hopkins University School of Medicine, Johns Hopkins Hospital — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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