Effects of Exercise on Memory in Healthy and Brain-Injured Individuals
Stopped early · Phase 1
Conditions studied: Traumatic Brain Injury
In brief
Background: \- Research has shown that one exercise session may improve a person s ability to recall information they learned before the exercise. Knowing how exercise changes brain activity to improve memory can help researchers understand how memory works and how to improve it in people with memory problems. This study compares two kinds of exercise on a stationary bike for their ability to temporarily improve memory on certain tests. Researchers will look at the effect of exercise on body chemistry by drawing blood and collecting saliva. Objectives: \- To understand how a single session of exercise affects memory testing in healthy people and people who have had traumatic brain injury (TBI). Eligibility: * Adults ages 18 through 45 with TBI. * Healthy adult volunteers, ages 18 through 45. Design: * Participants will be screened with medical history and physical exam. This will take about 1 hour. * Participants with TBI will also be screened with a test of their memory. This will take another hour. * Visit 1 will take about 3 hours. Participants will: \<TAB\>- Have a tube inserted in their arm for drawing blood during the tests. \<TAB\>- Take memory tests. They will look at pictures, symbols, and words, then answer questions. \<TAB\>- Give a saliva sample by chewing on a small sponge for 2 minutes. \<TAB\>- Exercise on a stationary bike. \<TAB\>- Take the memory tests again. \- Visit 2 will take place 1 week later. Participants will take the memory tests only.
Key facts
- Study ID
- NCT01939769
- Run by
- National Institute of Neurological Disorders and Stroke (NINDS)
- People needed
- 42
- Starts
- 2013-08-31
- Expected to finish
- 2017-08-28
- Last updated by the study team
- 2017-08-30
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Inability to give informed consent
- History of major neurological or psychiatric illness, e.g., neurodegenerative disorder, stroke, congenital or genetic disorder, currently symptomatic major depressive disorder, schizophrenia
- History of exercise intolerance
- Any finding on examination indicative of cardiac or respiratory compromise
- History of heart disease
- History of pulmonary disease, other than controlled, non-exercise-induced asthma
- History of uncontrolled diabetes
- Resting heart rate > 100 BPM
- Resting systolic blood pressure > 140 mmHg or diastolic blood pressure > 100 mmHg
- Peripheral condition making completion of the exercise protocol impossible, such as severe osteoarthritis or chronic pain
- Pregnancy
- For healthy subjects undergoing MRI:
- Ferromagnetic metal in the cranial cavity or eye, e.g. aneurysm clip, implanted neural stimulator, cochlear implant, or ocular foreign body
- Implanted cardiac pacemaker or auto-defibrillator or pump
- Non-removable body piercing
- Claustrophobia
- Inability to lie supine for two hours
- Any structural brain abnormality, such as tumor or stroke
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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