Infant Pulmonary Mechanics: High Flow Nasal Cannula Versus Nasal CPAP

Withdrawn before enrolling · Phase 1

Conditions studied: Respiratory Distress, Lung Injury

In brief

This study is designed to evaluate the effect of heated humidified high flow nasal cannula (HHHFNC) as compared to noninvasive nasal continuous positive airway pressure (NCPAP) on lung function as a measure of lung injury in preterm infants born at 28 to 37 weeks gestation requiring continuing respiratory support.

Key facts

Study ID

NCT01939067

Run by

Children's Hospital of Philadelphia

People needed

0

Starts

2014-03-01

Expected to finish

2014-03-01

Last updated by the study team

2015-09-15

Who can join

Age: any, up to 0. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Birth weight greater than or equal to 1000 grams.
• Gestational age at birth between 28 weeks and 37 weeks (28 0/7 to 37 6/7 weeks inclusive).
• Candidate for non-invasive respiratory support as a result of:
• An intention to manage the infant with non-invasive (no endotracheal tube) respiratory support.
• An intention to extubate an infant being managed with intubated respiratory support to non-invasive respiratory support.
• Subjects must have a guardian or acceptable surrogate capable of giving consent on his/her behalf.

You may not qualify if…

• Birth weight less than 1000 grams.
• Estimated gestation at birth less than 28 weeks or greater than 37 6/7 weeks.
• Active air leak syndrome.
• Subjects will not be eligible if they are not considered viable.
• Infants with abnormalities of the upper and lower airways
• Infants with significant abdominal or respiratory malformations .

Where it is running

• Pennsylvania Hospital — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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