Topical Tranexamic Acid (TXA) in Joint Arthroplasty
Completed · Phase 4
Conditions studied: Osteoarthritis, Hip Arthropathy, Shoulder Arthropathy
In brief
The objective of this study is to evaluate the efficacy of topical tranexamic acid (TXA) in decreasing blood loss following both shoulder arthroplasty and primary total hip arthroplasty. TXA functions to decrease blood loss by affecting the blood clotting system within the body. The investigators hypothesize that topical application of TXA prior to closure reduces postoperative bleeding as measured by absolute changes in postoperative hemoglobin levels and surgical drain output. In addition, use of topically applied tranexamic acid may reduce the need for transfusions, the rates of hematomas, infections, and length of hospital stay.
Key facts
- Study ID
- NCT01937559
- Run by
- The Hawkins Foundation
- People needed
- 188
- Starts
- 2013-04-01
- Expected to finish
- 2018-11-01
- Last updated by the study team
- 2020-05-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Shoulders: All adult patients over the age of 18 scheduled for a primary total arthroplasty or a primary reverse shoulder arthroplasty will be eligible for inclusion in the study.
- Hips: All adult patients over the age of 18 scheduled for a primary total hip arthroplasty will be eligible for inclusion in the study.
You may not qualify if…
- allergy to TXA, refusal of blood products, preoperative use of anticoagulant therapy within 5 days of surgery, history of seizures, renal failure (creatine clearance <30ml/min), bleeding disorders, venous thromboembolism (deep vein thrombosis and/or pulmonary embolism), significant cardiac history (myocardial infarction, angina, stroke, lower limb ischemia), or perioperative anemia (hemoglobin <11g/dl in females and < 12g/dl in males).
Where it is running
- Steadman Hawkins Clinic of the Carolinas - Greenville Health System — Greenville, South Carolina, United States
Full record on ClinicalTrials.gov
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