Self-regulatory Control and Eating: A Neuroimaging Study of Bulimia Nervosa
Completed
Conditions studied: Bulimia Nervosa
In brief
The purpose of this study will be to replicate previous findings of deficits in prefrontal activation during response inhibition tasks in bulimia nervosa and extend these findings by demonstrating similar deficiencies in activity during a functional behavioral task that requires the inhibition of eating. Findings from this study will potentially help to elucidate the underlying neural mechanisms of bulimia nervosa, and thus inform treatment and prevention efforts.
Key facts
- Study ID
- NCT01935401
- Run by
- Michael Lowe
- People needed
- 47
- Starts
- 2011-06-01
- Last updated by the study team
- 2014-10-07
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Female
- Right-handed
- Age 18-45
- Between 85 and 120% of ideal body weight based on height
- Currently meeting proposed DSM-5 criteria for Bulimia Nervosa (at least one objective bulimic episode and compensatory purging episode per week for the past three months)
- Purging via self-induced vomiting
- Duration of illness of at least 6 months
You may not qualify if…
- Current significant medical illness
- Any disorder or condition resulting in difficulty swallowing (e.g., dysphagia)
- History of neurological disorders or diseases (e.g., stroke, seizures, heart disease, head trauma with loss of consciousness)
- Drug or alcohol abuse in the past 6 months or any history of alcohol or drug dependence
- Use of marijuana or any other illegal drug (e.g., cocaine, heroin, ecstasy) in the week before the study visit
- IQ less than 75
- Pregnancy, lactation, or planning to become pregnant in the next year
- Allergy to sucrose, dairy, wheat, gluten, apples (i.e., any of the ingredients in the strawberry yogurt shake or in the standardized meal prior to study participation)
- Participants rating the strawberry yogurt shake as a 5 or lower on a 9-point category scale of liking will be excluded from further study
- Meeting the criteria for a diagnosis of Attention Deficit Hyperactivity Disorder
- Any other current major Axis I disorder, other than major depressive disorder (MDD) or generalized anxiety disorder (GAD)
- Inability to consent
- Prisoner
Where it is running
- Drexel University — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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