Cognitive Training for Depression II

Completed · Not applicable

Conditions studied: Major Depressive Disorder

In brief

This study is evaluating the effects of two brain training exercises on: memory, cognitive processing and depression symptoms.

Key facts

Study ID

NCT01934491

Run by

Icahn School of Medicine at Mount Sinai

People needed

51

Starts

2013-08-01

Expected to finish

2017-05-16

Last updated by the study team

2017-07-21

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Primary, current Axis I diagnosis of Major Depressive Disorder according to DSM-IV criteria and Ham-D-17 score between 16-27
• Age 18-55
• Able to give informed consent

You may not qualify if…

• A history of drug or alcohol abuse or dependence (DSM-IV criteria) within 6 months
• Visual impairment that would affect the ability to observe the computerized presentation of faces.
• Motor impairment that would affect the ability to provide a response by quickly pressing a button.
• Lifetime history of Bipolar spectrum disorders or schizophrenia spectrum disorders.
• Primary, current Axis I diagnosis other than Major Depressive Disorder
• Primary, current Axis II personality disorder.
• Currently attending a cognitive-behavioral psychotherapy regimen
• Acute suicidal or homicidal risk (evidenced by suicidal or homicidal attempt within 6 months of screening)
• Pregnancy in women. Pregnant women are excluded from the study because research has shown that hormonal changes that occur during pregnancy can mimic and/or influence symptoms of depression. Including patterns of mood and cognition. These mood and cognitive changes could mask the effect of the cognitive training in this study, so pregnant women will be excluded for that reason.
• Enrolled participants can be currently taking medication but must be stabilized on their medication regimens before enrolling in the study (i.e., no medication has been started within 8 weeks, stopped within 6 weeks or titrated up or down within 4 weeks of study entry). Accordingly, if a patient's medication status must change during the course of the study, we will discontinue them in the study. We do not anticipate that this will occur frequently, as again, patients' medication regimens must be stable before enrolling in the study. No medications will be discontinued for the purpose of enrollment into the study.
• Subjects must exhibit no or only moderate alcohol use. Subjects with current excessive use of alcohol (> 8 ounces/day for men and > 6 ounces/day for women) are ineligible for participation, as such drug use could confound the results.

Where it is running

• Icahn School of Medicine at Mount Sinai — New York, New York, United States

Full record on ClinicalTrials.gov

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