NIR Hypoxia Imaging of Breast Tumor Response to Neoadjuvant Chemotherapy in Vivo
Stopped early
Conditions studied: Breast Cancer
In brief
The purpose of this study is to determine whether an experimental alternative imaging method, Near Infrared Spectroscopy (abbreviated as NIR), can be used with a controlled respiratory system to examine the breasts for cancer. The NIR system uses light beams to produce an image or picture of the inside of the breast. The respiratory system will help researchers get more information about the breast tissue by changing the amount of oxygen the tissue receives during NIR imaging.
Key facts
- Study ID
- NCT01934114
- Run by
- Dartmouth-Hitchcock Medical Center
- People needed
- 8
- Starts
- 2010-08-01
- Expected to finish
- 2015-09-01
- Last updated by the study team
- 2016-04-28
Who can join
Age: 25 and older, up to 76. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- NORMAL cohort
- Breast size and epithelial integrity adequate to allow NIR imaging exams
- No serious associated psychiatric illnesses
- Female, ≥25 and <76 years old
- Written informed consent
- UNDER TREATMENT cohort
- Locally advanced breast cancer, with or without metastatic disease, defined as being clinically appropriate for neoadjuvant therapy
- Breast size and epithelial integrity adequate to allow NIR imaging exams
- No serious associated psychiatric illnesses
- Female, ≥25 and <76 years old
- Written informed consent
You may not qualify if…
- both cohorts
- Pre-existing respiratory conditions:
- severe chronic obstructive pulmonary disease (including chronic bronchitis and/or emphysema)
- Other respiratory or lung conditions which would place the patient at risk
- presence of any other significant cardiac or pulmonary symptoms, such as moderate or severe dyspnea on exertion, orthopnea, or paroxysmal nocturnal dyspnea
- Congestive heart failure
- Intolerance of hyperoxia or hypercarbia as delivered by the RespirAct breathing circuit
- Pregnancy
Where it is running
- Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States
Full record on ClinicalTrials.gov
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