The Impact of Quantitative Neuromuscular Monitoring in the PACU on Residual Blockade and Postoperative Recovery
Completed
Conditions studied: Muscle Weakness
In brief
Neuromuscular blocking drugs (NMBDs) provide anesthesiologists with powerful intraoperative tools, but their use carries the potential risk of serious postoperative complications. NMBD-induced muscle weakness that lingers into the postoperative period, known as postoperative residual curarization (PORC), is present in as many as 40% of all patients that receive neuromuscular blocking agents. The Post Anesthesia Care Unit will be introducing monitoring as part of standard of care. This study will collect data about patients who receive NMBDs and examine the impact of monitoring on incidences of PORC. Our study is designed to test the following hypotheses: Hypothesis 1: The initiation of quantitative TOF monitoring as part of the standard PACU entry evaluation will change practitioner behavior in a manner that decreases the incidence of PORC in surgical patients at VUMC. Hypothesis 2: The initiation of the routine TOF monitoring program will decrease the incidence of short- and long-term postoperative complications at VUMC.
Key facts
- Study ID
- NCT01933841
- Run by
- Vanderbilt University Medical Center
- People needed
- 201
- Starts
- 2016-08-01
- Expected to finish
- 2017-07-01
- Last updated by the study team
- 2019-09-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Surgical patients > 18 years of age
- Received one or more NMBDs during surgery
- Surgery took place during the first 120 days following the introduction of TOF monitoring in the PACU
You may not qualify if…
- Surgical patients < 18 years of age
- Received no NMBDs during surgery
- Transfer from the OR to the PACU was delayed (by high PACU volume, for example)
- Had a procedure or has a preexisting condition that prevents accurate monitoring
Where it is running
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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