Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative Status

Completed · Not applicable

Conditions studied: Obesity, Metabolic Syndrome, Hyperuricemia

In brief

The purpose of this study is to learn more about what is the effect of uric acid on oxidative stress and on the way the body metabolizes sugar in obese people. Understanding this may lead to better diseases such as diabetes.

Key facts

Study ID

NCT01931527

Run by

Washington University School of Medicine

People needed

31

Starts

2006-07-01

Expected to finish

2012-11-01

Last updated by the study team

2018-08-14

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• obese (BMI 30-45 kg/m²);
• serum UA concentration either ≥5 mg/dL or ≤4.0 mg/dL (297 µmol/L)],

You may not qualify if…

• renal dysfunction (serum creatinine >1.5 mg/dL);
• pregnancy or lactating;
• take urate-lowering agents, thiazide diuretics, prednisone or medications containing aspirin or other salicylates;
• history of xanthinuria, type 2 diabetes or other significant organ system dysfunction;
• have G6PD deficiency;
• use hormone-replacement or oral-contraceptive therapy;
• smoke tobacco;
• anemic (Hb <10 g/dl)

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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