Acute D2 Receptor Blockade Induced Neuronal Network Changes in Human Volunteers
Completed · Not applicable · Has a placebo group
Conditions studied: Imaging of the Brain and Antipsychotics, Neuronal Network Changes
In brief
To detect the effect of second-generation antipsychotic drug on the neural activity.
Key facts
- Study ID
- NCT01931059
- Run by
- Northwell Health
- People needed
- 11
- Starts
- 2013-07-01
- Expected to finish
- 2016-07-01
- Last updated by the study team
- 2018-04-30
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Between 18 and 60 years of age
- Subject is competent to provide informed consent
You may not qualify if…
- Mini Mental Status Exam is less than 28
- Past or current history of any psychotic illness in the subject or in first degree family members
- Self report of illicit drug use (except marijuana) in the past. Use of marijuana during the last 3 month...
- Any use of antipsychotic in the past.
- Any neuro-anatomical lesions on previous brain imaging
- Any use of D2 receptor blocking agent (such as antiemetics) in the last two weeks.
- Any use of any psychotropic medications (SSRI, mood stabilizers, benzodiazepines, stimulants) in the last month.
- MRI contraindications
- Any cardiovascular or cerebrovascular diseases or conditions that predispose patients to hypotension (eg. dehydration, hypovolemia, antihypertensive medication)
- Subjects with diabetes mellitus, metabolic syndrome, hepatic or renal impairment, seizure disorder and any neurological disorder
- QTc interval longer than 450 ms for male and 470 ms for female
- Subjects who used any medications in the last two weeks (to avoid any possible drug-drug interactions)
- Pregnancy
- Individuals who are illiterate and/or visually impaired
Where it is running
- Zucker-Hillside Hospital — Glen Oaks, New York, United States
Full record on ClinicalTrials.gov
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