Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving

Completed · Phase 2

Conditions studied: Cocaine Addiction

In brief

We propose that the systemic administration of lidocaine following the induction of cue-induced craving, relative to saline plus cue-induced craving or lidocaine without cue-induced craving, will block the reconsolidation of cue memories. This will lead to a reduction in cue-induced craving upon repeated testing as well as subsequent cocaine use and basal craving.

Key facts

Study ID

NCT01929343

Run by

Bryon Adinoff

People needed

84

Starts

2014-01-01

Expected to finish

2016-03-01

Last updated by the study team

2020-12-31

Who can join

Age: 25 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 25-60 years old
• men or women
• any race or ethnicity
• cocaine addition is primary present and lifetime drug of abuse
• live locally

You may not qualify if…

• Patients with active DSM (Diagnostic Statistical Manual)-IV other Substance Dependence (except nicotine) within the previous three months, Affective Disorder, Schizophrenic Disorders.
• significant cognitive impairment (WTAR<70) (Wechsler Test of Adult Reading <70)..
• use of tricyclic anti-depressants, benzodiazepines, cimetidine, mood stabilizers, opioids, lithium, sympathomimetics, anticonvulsants, sedative/hypnotics, β-blockers, or dopamine agonists will be excluded from the study.
• Medical conditions that might limit cooperation (e.g. dementia) or put the patient at medical risk (i.e. significant hematologic, hepatic, renal, or cardiovascular pathology - particularly arrhythmias) will be excluded.
• Patients with congenital or idiopathic methemoglobinemia or patients taking medications associated with increased risk of methemoglobinemia (including sulfonamides, acetaminophen, acetanilid, aniline dyes, benzocaine, chloroquine, dapsone, naphthalene, nitrates and nitrites, nitrofurantoin, nitroglycerin, nitroprusside, pamaquine, paraaminosalicylic acid, phenacetin, phenobarbital, phenytoin, primaquine, quinine) will be excluded.
• Patients with past or present neurologic disorders (i.e. severe head trauma, transient ischemic attacks, stroke, tumor, etc.) will be excluded. - Active suicidal ideation, pregnant or nursing women, and prisoners will be excluded from the study.

Where it is running

• UT Southwestern Medical Center at Dallas, Division on Addictions — Dallas, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.