Diffuse Myocardial Fibrosis in Fontan Patients

Completed

Conditions studied: Congenital Heart Disease, Single Ventricle, Myocardial Fibrosis

In brief

The purpose of this protocol is to measure the relaxation of the heart in subjects with single ventricles who have undergone the surgical Fontan procedure. We will do this by measuring relaxation with MRI, echocardiography, and cardiac catheterization and compare to blood levels that measure heart scarring. We will also measure relaxation before and after boluses of intravenous (IV) fluids to see if the relaxation changes when there is more fluid in the heart. Measurements of heart relaxation will be obtained from the MRI, echocardiogram, and cardiac catheterization for each patient and compared to blood markers of heart scarring. We aim to compare all of these measurements to see if we can accurately identify heart scarring and, if present, how much it correlates with impaired heart relaxation.

Key facts

Study ID
NCT01929174
Run by
Oregon Health and Science University
People needed
18
Starts
2013-08-01
Expected to finish
2019-03-01
Last updated by the study team
2019-04-16

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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