Ultrasound Characterization of Ovarian Follicle Dynamics in Women With Amenorrhea
Completed
Conditions studied: Oligomenorrhea, Amenorrhea, Polycystic Ovary Syndrome (PCOS)
In brief
In women with regular menstrual cycles, antral follicles have been shown to grow in synchronous cohorts, called waves, 2-3 times in a menstrual cycle. It is unknown whether these waves of follicle growth also occur in women with amenorrhea or if there is abnormal/absent follicle growth. Further, oligo- or amenorrhea has been associated with metabolic disturbances, such as over- or under-nutrition, central obesity and insulin resistance. Yet, mechanisms whereby metabolic factors influence folliculogenesis in women are poorly understood. To understand potential mechanisms, the investigators plan to characterize follicle growth dynamics in women with or without regular menstrual cycles and identifying key metabolic differences in these women which may be important in normal follicle development and fertility.
Key facts
- Study ID
- NCT01927432
- Run by
- Cornell University
- People needed
- 73
- Starts
- 2011-09-01
- Expected to finish
- 2021-09-01
- Last updated by the study team
- 2024-02-09
Who can join
Age: 18 and older, up to 35. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Between 18 and 35 years
- BMI ≥ 18 kg/m2
- If ≥ 21 years old, must have had healthy pelvic exam w/in past 2 years
- Either:
- Regular menstrual cycles (21-35 days);
- Irregular menstrual cycles (>36 days) with or without a previous diagnosis of PCOS from a primary care provider
You may not qualify if…
- Current use of medication(s) known or suspected to interfere with reproductive function (eg. oral contraceptives) or insulin sensitivity
- Pregnant or breastfeeding
- Not otherwise healthy
Where it is running
- Human Metabolic Research Unit, Cornell University — Ithaca, New York, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.