Endothelial Function in Young Hispanic Adults at Risk for Type 2 Diabetes
Completed
Conditions studied: Obesity, Insulin Resistance
In brief
Diabetes is a major public health problem. Hispanics/Latinos are known to be at higher risk for type 2 diabetes. The function of the endothelium has played a key role in the understanding of vascular complications in people with diabetes. Endothelial function and vascular reactivity are impaired not only in white adults with type 2 diabetes but also in those at risk for the disease by virtue of having impaired glucose tolerance or parental history of type 2 diabetes. Whether this finding is applicable to hispanics is not known. The investigators plan to assess the endothelial function and vascular reactivity in young Hispanic adults at risk of developing type 2 diabetes by virtue of being obese and belonging to a minority population.
Key facts
- Study ID
- NCT01926938
- Run by
- Joslin Diabetes Center
- People needed
- 44
- Starts
- 2003-05-01
- Expected to finish
- 2013-01-01
- Last updated by the study team
- 2013-08-21
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Group 1:
- Age between 18-40 years;
- Hispanic (we will consider a subject being Hispanic if both parents are reported as Hispanics when asked the following question: "What ethnic group do you consider that you belong to?");
- History of type 2 diabetes in one or both parents;
- BMI above 27;
- Not have participated in any exercise program for the 6 months prior to the beginning of the study.
- Group 2:
- Age between 18-40 years;
- Hispanic (same criteria as above );
- No history of type 2 diabetes in any first degree relative;
- BMI under 25;
- Not have participated in any exercise program for the 6 months prior to the beginning of the study.
You may not qualify if…
- diabetes, glucose intolerance, pregnancy, smoking, cardiovascular disease, uncontrolled hypertension, renal disease, proteinuria, cancer, infectious diseases, severe GI diseases, lung disease, electrolyte abnormalities, anemia, endocrine disorders, severe dyslipidemia, peripheral vascular disease, medications: beta-blockers, any diuretic, calcium channel blockers, ACE inhibitors, angiotensin receptor blockers, niacin, glucocorticoids, any antineoplastic agent, antibiotics, psychoactive agents, bronchodilators or insulin.
Where it is running
- Joslin Diabetes Center — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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