Safety Study of Intratumoral Injection of Clostridium Novyi-NT Spores to Treat Patients With Solid Tumors That Have Not Responded to Standard Therapies

Completed · Phase 1

Conditions studied: Solid Tumor Malignancies

In brief

This protocol will examine the safety of intratumoral administration of Clostridium Novyi-NT spores in patients with treatment-refractory solid tumor malignancies. This investigational study will measure anti-tumor activity of C. novyi-NT administered intratumoral in patients with treatment-refractory solid tumor malignancies.

Key facts

Study ID

NCT01924689

Run by

BioMed Valley Discoveries, Inc

People needed

24

Starts

2013-10-01

Expected to finish

2017-10-31

Last updated by the study team

2019-09-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of an advanced solid tumor malignancy. There must be a target tumor which is measureable, palpable or clearly identifiable under ultrasound or radiographic guidance and amenable to percutaneous injection of C. novyi-NT spores. The targeted lesion must have a longest diameter ≥ 1 cm and ≤ 12 cm and be measurable as defined by RECIST 1.1 criteria. The target lesion must not be located in either the thoracic, abdominal or pelvic cavities or in the brain. There must be no clinical, no functional, and no radiographic evidence of bone involvement at the site of the target lesion.
• History of prior treatment with at least one line of systemic anticancer therapy, when an approved systemic therapy is available, and no curative option is available for continued treatment.
• At least 4 weeks have elapsed since the completion of major surgery, and the patient has fully recovered from this surgery and any post-surgical complications.
• Eastern Cooperative Oncology Group (ECOG) performance status of 2 or less.
• Patient is at least 18 years of age.
• Patient is capable of giving informed consent.
• Patient of childbearing potential (defined by the clinical sites' standards) is using adequate birth control measures (e.g., barrier method with spermicide; intrauterine device; implantable or injectable hormonal contraceptives; surgical sterilization) for the duration of the study and will continue to use such precautions for 12 months after receiving treatment.
• Patient has no significant valvular heart disease (trace or mild valvular stenosis or regurgitation is allowed).
• Patient is able to stay within 45 minutes driving time of an emergency room for 28 days after doing.
• The patient has a caregiver for 28 days after dosing.

You may not qualify if…

• Positive pregnancy test.
• Serum creatinine level > 1.5 x the upper limit of normal (ULN), chronic renal failure requiring hemodialysis or peritoneal dialysis.
• Patient has any of the following hematologic parameters:
• Platelet count equal to or less than 100,000/mm3
• Hemoglobin less than 9.0 g/dL
• Absolute neutrophil count (ANC) less than 1,000 /mm3
• Oxygen saturation (Sp02) of less than 95% on room air.
• Mean arterial blood pressure (BP) of less than 70 mmHg.
• Glasgow Coma Score (GCS) of less than 15.
• Treatment with an investigational drug within the past 30 days or 5 half-lives of that drug, whichever is shorter.
• Documented primary brain malignancy or brain metastases.
• Clinically significant ascites or clinical evidence or history of portosystemic hypertension or cirrhosis.
• Laboratory evidence of hepatic dysfunction indicated by any of the following:
• Bilirubin ≥ 1.5 x the ULN
• Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) above 2.5X the ULN
• Alkaline phosphatase above 2.5X the ULN
• International normalized ratio (INR) greater than 1.3
• Patient has a foreign body which in the opinion of the treating investigator could be difficult to manage in case of infection (e.g. prosthetic hip).
• Clinically significant pleural effusion.
• Clinically significant pericardial effusion, circumferential pericardial effusion, or any effusion greater than 1.0 cm at any location around the heart.
• Need for ongoing treatment with an immunosuppressive agent.
• History of solid organ transplantation (with the exception of a corneal transplant > 3 months prior to screening).
• History of an ischemic insult in the previous 12 months (myocardial infarction, cerebral vascular accident, ischemic tissue from injury, transient ischemic attack.
• History of a significant medical illness deemed by the PI or local investigators as unsuitable for the trial. For example:
• i. Symptomatic congestive heart failure ii. Psychiatric Illness/social situation that may make study dangerous iii. Unstable angina pectoris

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States
• Memorial Sloan Kettering Cancer Center — New York, New York, United States
• Albert Einstein College of Medicine — The Bronx, New York, United States
• Cleveland Clinic Foundation — Cleveland, Ohio, United States
• UT M.D. Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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