Multiple Dose Trial Examining Dose Range, Escalation and Efficacy of Oral Semaglutide in Subjects With Type 2 Diabetes

Completed · Phase 2 · Has a placebo group

Conditions studied: Diabetes, Diabetes Mellitus, Type 2

In brief

This trial is conducted globally. The aim of the trial is to examine the dose range, escalation and efficacy of oral semaglutide in subjects with type 2 diabetes.

Key facts

Study ID

NCT01923181

Run by

Novo Nordisk A/S

People needed

632

Starts

2013-12-02

Expected to finish

2014-12-11

Last updated by the study team

2021-01-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• BMI above or equal to 25 and below or equal to 40 kg/m\^2
• Subjects diagnosed with T2D (Type 2 diabetes) treated with diet and exercise and/or who have been on a stable dose of metformin for at least 30 days prior to screening
• HbA1c 7.0-9.5% (53-80 mmol/mol) (both inclusive)

You may not qualify if…

• Subjects on selected oral medication with a narrow therapeutic window, such as warfarin, digoxin, tricyclic antidepressants, lithium, aminophylline, theophylline and anticonvulsants
• History of chronic pancreatitis or idiopathic acute pancreatitis
• Chronic malabsorption, regardless of aetiology
• History of Crohn's disease, ulcerative colitis, or other inflammatory bowel disease
• Treatment with glucose lowering agent(s) other than metformin as stated in the inclusion criteria in a period of 90 days before the screening visit

Where it is running

• Novo Nordisk Investigational Site — Chula Vista, California, United States
• Novo Nordisk Investigational Site — Long Beach, California, United States
• Novo Nordisk Investigational Site — Poway, California, United States
• Novo Nordisk Investigational Site — Santa Ana, California, United States
• Novo Nordisk Investigational Site — Spring Valley, California, United States
• Novo Nordisk Investigational Site — Walnut Creek, California, United States
• Novo Nordisk Investigational Site — Colorado Springs, Colorado, United States
• Novo Nordisk Investigational Site — Denver, Colorado, United States
• Novo Nordisk Investigational Site — Jacksonville, Florida, United States
• Novo Nordisk Investigational Site — Miami, Florida, United States
• Novo Nordisk Investigational Site — Plantation, Florida, United States
• Novo Nordisk Investigational Site — South Miami, Florida, United States
• Novo Nordisk Investigational Site — Athens, Georgia, United States
• Novo Nordisk Investigational Site — Conyers, Georgia, United States
• Novo Nordisk Investigational Site — Addison, Illinois, United States
• Novo Nordisk Investigational Site — Chicago, Illinois, United States
• Novo Nordisk Investigational Site — Wichita, Kansas, United States
• Novo Nordisk Investigational Site — Rockville, Maryland, United States
• Novo Nordisk Investigational Site — Las Vegas, Nevada, United States
• Novo Nordisk Investigational Site — Las Vegas, Nevada, United States
• Novo Nordisk Investigational Site — New York, New York, United States
• Novo Nordisk Investigational Site — New York, New York, United States
• Novo Nordisk Investigational Site — Rochester, New York, United States
• Novo Nordisk Investigational Site — Asheville, North Carolina, United States
• Novo Nordisk Investigational Site — Tucson, Arizona, United States

Full record on ClinicalTrials.gov

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