The Effect of Anticholinergics on Cognitive Function in the Elderly

Completed · Phase 4 · Has a placebo group

Conditions studied: Mental Competency, Urinary Bladder, Overactive, Cognitive Function

In brief

Anticholinergic medication is used to treat overactive bladder (OAB). A known side effect of this medication is cognitive dysfunction. OAB is more prevalent in the elderly population - a group that also has a higher baseline risk of cognitive dysfunction. Our objective is to evaluate the effect of an anticholinergic medication on cognitive function in elderly women.

Key facts

Study ID

NCT01922115

Run by

University of North Carolina, Chapel Hill

People needed

59

Starts

2013-06-01

Expected to finish

2015-06-01

Last updated by the study team

2017-03-22

Who can join

Age: 50 and older, up to 99. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Female 50 or older
• Diagnosis of OAB (ICS definition)
• English literacy
• Ability to swallow oral medication
• Cognitive ability to give consent

You may not qualify if…

• Dementia/Depression/Delirium
• Current anticholinergic use (requires 2 week washout period)
• Current cholinesterase
• Urinary or gastric retention
• Severe decreased gastrointestinal motility
• Uncontrolled narrow-angle glaucoma
• Myasthenia gravis
• Diagnosis fo renal impairment (creatinine clearance <30 mL/min)

Where it is running

• Unc Chapel Hill Urogynecology A2 Clinic — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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