The Pathogenesis of Hepatitis C Virus Vertical Transmission

Completed

Conditions studied: Hepatitis C, Infection Transmission, Maternal-Fetal

In brief

To evaluate for the presence of HCV Core protein, HCV RNA and SPP in the placenta and fetal membranes using paraffin-embedded sections and post-delivery specimens respectively. In parallel, we will assess placental tissue for evidence of HCV infection using a novel in situ hybridization technique and translate our in vitro findings to these in vivo samples. Our overall hypothesis is that cytotrophoblasts at the maternal-fetal interface within the placenta serve as a "barrier" that must be crossed during vertical transmission and that cytotrophoblasts are permissive to HCV at a low level that may be enhanced under certain conditions. By comparing the regulation of key steps in the intracellular life cycle of HCV in cytotrophoblasts to highly permissive hepatocytes, significant differences in HCV regulation should be revealed. Based on our preliminary data, our working hypothesis is that HCV Core protein is differentially processed in cytotrophoblasts compared to hepatocytes.

Key facts

Study ID

NCT01921400

Run by

University of North Carolina, Chapel Hill

People needed

38

Starts

2013-01-01

Expected to finish

2017-12-01

Last updated by the study team

2018-04-09

Who can join

Age: any. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Pregnant women with HCV infection
• Pregnant women without HCV infection

You may not qualify if…

• None

Where it is running

• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
• Cairo University — Giza, Egypt

Full record on ClinicalTrials.gov

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