Platelet Rich Plasma vs Hyaluronic-Acid in Hip OA (Osteoarthritis)

Completed · Not applicable

Conditions studied: Hip Osteoarthritis

In brief

The objective of this study is to compare the clinical efficacy of intra-articular injections of autologous platelet rich plasma (PRP) vs hyaluronic acid (HA) for symptomatic early osteoarthritis (OA) of the hip. Secondarily, this study aims to determine the feasibility and safety of treating early OA of the hip with HA and PRP.

Key facts

Study ID

NCT01920152

Run by

University of Colorado, Denver

People needed

38

Starts

2013-08-01

Expected to finish

2019-12-05

Last updated by the study team

2021-03-03

Who can join

Age: 30 and older, up to 72. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female age 30-72 inclusive.
• Symptomatic early OA of the hip (Kellgren-Lawrence Grade 1-2-3) documented by x-ray taken within the past 6 months.
• Women of childbearing potential will be allowed to enroll but must be willing to practice one highly effective method of contraception (oral, injectable or implanted hormonal methods of contraception, placement of an intrauterine device (IUD) or intrauterine system (IUS) condom or occlusive cap with spermicidal foam/gel/film/cream/suppository, male sterilization, or true abstinence) throughout the study.

You may not qualify if…

• Patients with polyarticular disease.
• Patients with major conditions such as poorly control diabetes, Cardiac Heart Failure (CHF), Chronic Obstructive Pulmonary Disease (COPD) or untreated depression
• Patients with known blood disorders (Blood disorders (thrombopathy, thrombocytopenia, anemia with hemoglobin <9g/dL).
• Patients who had intra-articular treatment with steroids within 6 months of randomization in this study or received more than 3 previous intra-articular steroid injections to the effected hip.
• Patients who are pregnant or nursing at the time of consent.
• Patients with inflammatory arthritic conditions (e.g. rheumatoid arthritis)
• Non-English speaking patients. (Scores used for evaluation have not been validated in Spanish)
• Patients who had previous hip surgery
• Additional disabilities in any of the lower limbs that would interfere with any of the clinical assessments.
• Chronic use of NSAID (defined as taking NSAID regularly every week for the last 6 months), steroids or chemotherapy drugs
• Treatment with NSAIDs within 2 days prior to randomization in this study
• Patients with a BMI over 30. Due to the fact that this study utilize an injection technique which may be inaccurate in obese subjects.

Where it is running

• University of Colorado, Hip Preservation Center, Orthopedic Department — Boulder, Colorado, United States

Full record on ClinicalTrials.gov

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