Loaded and Unloaded Magnetic Resonance (MR) Imaging of Meniscus-Cartilage-Trabecular Bone in Osteoarthritis

Completed · Not applicable

Conditions studied: Knee Osteoarthritis

In brief

The objective of this project is to determine the effects of gait-retraining on articular cartilage composition, gait mechanics, pain and function in persons with mild to moderate knee osteoarthritis (OA).

Key facts

Study ID

NCT01919736

Run by

University of California, San Francisco

People needed

30

Starts

2013-09-01

Expected to finish

2016-12-01

Last updated by the study team

2019-11-18

Who can join

Age: 35 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women
• At least 35 years of age
• Mild OA patients with arthritic knee symptoms and KL score of 1-2
• Severe OA patients with arthritic knee symptoms and KL score of 3-4
• Knee symptoms in OA patients is defined as pain, aching, or stiffness on most days of a month during the past year or use of medication for treatment of knee pain on most days of a month during the past year
• self reported knee pain (defined as medial compartment knee pain at least 1 day per week during each of the 6 weeks prior to participation) and at least 3 of the following 6 clinical indicators: Age>50 years; morning stiffness<30 minutes duration; crepitus on active motion; tenderness of the bony margins of the knee joint; bony enlargement at the knee; and lack of palpable warmth of the synovium

You may not qualify if…

• current use of investigational drug
• conditions other than OA which limit lower extremity function and mobility and/or would confound the evaluation of function (e.g., clinically significant spinal disc degeneration, painful or dysfunctional feet, peripheral vascular disease, lumbar radiculopathy, trochanteric bursitis, hip pain, lumbar pain)
• Patients with metallic fragments in the eyes, vascular clips, pacemakers, and other contraindications to MRI
• History of joint replacement, intra-articular fracture, osteotomy, arthroplasty or meniscectomy of the signal knee
• History of other disease that may involve the study joint including systemic inflammatory disease, crystalline disease, knee infection of the signal knee, avascular necrosis, Paget's disease or tumors
• Self reported heart condition that limits any daily physical activity
• Patients who are pregnant

Where it is running

• China Basin Imaging Center — San Francisco, California, United States

Full record on ClinicalTrials.gov

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