Characterization of Myocardial Blood Flow Measurements Using Lexiscan®™ (Regadenoson) (Lexiscan®™) Rubidium-82 Myocardial Perfusion PET: A Temporal-Dependency Investigation

Completed · Phase 4

Conditions studied: Myocardial Blood Flow Reserve

In brief

The purpose of this study is to evaluate the consistency of quantitative peak stress myocardial blood flow and myocardial blood flow reserve following a 10 second, 1 minute, 2 minute or 4 minute delay in beginning the rubidium-82 infusion post-Lexiscan (regadenoson) injection. It is anticipated that there will be no or minimal difference between the four delay times.

Key facts

Study ID

NCT01919450

Run by

Timothy M. Bateman, MD

People needed

80

Starts

2013-07-01

Expected to finish

2016-04-01

Last updated by the study team

2018-08-16

Who can join

Age: 40 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Recent normal clinically-indicated exercise myocardial perfusion SPECT, treadmill maximal exercise test or exercise echocardiographic study
• No change in symptoms between the exercise study and PET study
• Capable of providing written informed consent
• BMI 25-32 kg/m2

You may not qualify if…

• Diabetes mellitus
• Coronary Artery Calcium Score >25
• Second and Third Degree Atrioventricular Node Block
• Sinus Node Dysfunction
• Recent Syncope of unknown etiology
• Left ventricular hypertrophy per ECG or echocardiography
• Slowed circulation times
• Active wheezing or with acute asthmatic or bronchospastic attacks requiring changes in therapy within the past 30 days.
• Patients that have experienced a previous hypersensitivity reaction thought to be related to Lexiscan

Where it is running

• Saint Luke's Hospital Imaging Center — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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