Effect of Octreotide on the Colonic Motility in Pediatric Patients
Completed · Phase 4
Conditions studied: Colonic Motility Index, Constipation
In brief
The research study is designed to test how a medication called octreotide affects the motility (contraction or squeezing) of the colon (large intestine). Investigators are investigating whether octreotide can increase contraction and movement in the colon.
Key facts
- Study ID
- NCT01917773
- Run by
- Indiana University
- People needed
- 13
- Starts
- 2013-08-01
- Expected to finish
- 2014-06-01
- Last updated by the study team
- 2015-12-21
Who can join
Age: 1 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female and undergoing colonic manometry for a routinely accepted indication including: evaluation of chronic constipation, unexplained abdominal distension (Should have had previous diagnostic work up), recurrent fecal impaction, post Hirschsprung's disease repair, chronic intestinal pseudo-obstruction, or suspected colonic dysmotility of any other cause.
- Children aged 12 months or older who are undergoing colonic motility under the supervision of Dr. Joseph Croffie at Riley Hospital.
- In the investigator's judgment, parent(s)/guardian(s) is mentally competent to provide informed consent to participate in the study.
You may not qualify if…
- • Subjects with known or suspected allergy to octreotide.
- Subjects with known prolonged corrected QT interval (QTc) Syndrome or highest risk QTc-Prolonging Agents (including mifepristone).
- Subjects with known history of ventricular arrhythmia.
- Subjects with history of any organ transplant who are taking cyclosporine at the time of the motility study.
- Subjects with history of small bowel transplant.
- Subjects less than 12 months old.
- Subjects with severe renal impairment
- Subjects with severe hepatic impairment
- Subjects taking bromocriptine, insulin, oral hypoglycemic agents, beta blockers, calcium channel blockers, quinidine, terfenadine, pimozide, sildenafil, tadalafil, and any agents to control fluid and electrolyte imbalance
Where it is running
- Motility Laboratory, Division of Pediatric Gastroenterology, Hepatology and Nutrition at the James Whitcomb Riley Hospital for Children, — Indianapolis, Indiana, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.