11C-acetate/18Fluorodeoxyglucose-FDG PET/CT and Cardiac MRI in Pulmonary Hypertension

Completed · Phase 2

Conditions studied: Pulmonary Hypertension

In brief

This study is looking at differences in metabolism and functional imaging between pulmonary hypertension subjects with normal right ventricular function and persistent right ventricular dysfunction.

Key facts

Study ID

NCT01917136

Run by

University of Pennsylvania

People needed

21

Starts

2013-08-01

Expected to finish

2018-10-01

Last updated by the study team

2019-02-05

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participation in the companion treatment protocol "A randomized, double-blind, placebo controlled, multi-center study to assess the effect of ranolazine on outcomes in subjects with pulmonary hypertension and right ventricular dysfunction accompanied by a comparative study of cellular metabolism in subjects with pulmonary hypertension with and without right ventricular dysfunction"

You may not qualify if…

• Pregnancy or lactation: Women of childbearing potential must have a negative urine or blood pregnancy test on the day of the PET/CT scan.
• Severe anxiety or claustrophobia prohibiting completion of imaging
• Inability to tolerate imaging procedures (1 hour MRI, 30 min and 15 min PET)
• Implantable cardioverter-defibrillator, Pacemaker, hazardous metallic implants or any other contraindication to MRI.
• Uncontrolled diabetes mellitus with fasting glucose > 150 mg/dL

Where it is running

• University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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