18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic Hypoglycemia

Available (expanded access)

Conditions studied: Congenital Hyperinsulinism (CHI), Beckwith-Wiedemann Syndrome, Insulinoma

In brief

This purpose of this study is to determine the ability of an 18F-fluoro-L-dihydroxyphenylalanine (18F-DOPA) PET (Positron Emission Tomography) scan to detect a focal lesion of hyperinsulinism and determine the location in patients with congenital hyperinsulinism, Beckwith Wiedemann Syndrome and suspected insulinoma. Safety data will be collected.

Key facts

Study ID

NCT01916148

Run by

Children's Hospital of Philadelphia

Last updated by the study team

2026-04-27

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects of any age with hyperinsulinemic hypoglycemia, diagnosed by a fasting test and/or response to glucagon stimulation.
• Subjects who are eligible for pancreatic surgery regardless of prior pancreatic surgery

You may not qualify if…

• Pregnant or lactating females
• Any other major illness or condition that in the investigator's judgment will substantially increase the risk associated with the subject's participation in this study
• Subjects who are not a candidate for pancreatic surgery

Where it is running

• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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