Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery

Completed · Phase 1 · Has a placebo group

Conditions studied: Adenocarcinoma of the Prostate, Recurrent Prostate Cancer, Stage I Prostate Cancer, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer, Stage III Prostate Cancer, Stage IV Prostate Cancer

In brief

This randomized pilot phase I trial will evaluate if quercetin enhances the uptake of green tea polyphenols in the prostate tissue of men taking green tea extract and undergoing radical prostatectomy. Side effects of green tea extract and quercetin in combination with green tea extract will also be evaluated. In preclinical studies, green tea polyphenols have anticancer and cancer preventative effects in a number of malignancies. Likewise, in preclinical studies quercetin was found to enhance the anticancer effects of green tea. This trial is designed to translate these findings forward in a short-term human intervention trial.

Key facts

Study ID

NCT01912820

Run by

Jonsson Comprehensive Cancer Center

People needed

32

Starts

2014-01-01

Expected to finish

2021-06-10

Last updated by the study team

2021-06-23

Who can join

Age: 40 and older, up to 75. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Subjects consent to participate in the trial
• The subject has a diagnosis of adenocarcinoma of the prostate
• The subject is scheduled to undergo radical prostatectomy
• The subject agrees to stop consuming tea or tea-containing products and quercetin supplements throughout the entire intervention period except for the green tea extract and quercetin provided during study intervention

You may not qualify if…

• History of hepatitis or liver dysfunction
• Ongoing alcohol abuse
• Significant medical or psychiatric conditions that would make the patient a poor protocol candidate
• Prior sensitivity or allergic reaction to tea, tea products or tea and quercetin supplements
• Allergies to multiple food items or nutritional supplements
• Taking luteinizing hormone-releasing hormone (LHRH) agonists, androgen receptor blocking agents, finasteride, or has undergone bilateral orchiectomy

Where it is running

• Veterans Administration Los Angeles Healthcare System — Los Angeles, California, United States
• Jonsson Comprehensive Cancer Center — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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