Triadic Interactions of Families With Autism and Oxytocin
Withdrawn before enrolling · Phase 1 · Has a placebo group
Conditions studied: Autism Disorder
In brief
The study will investigate the effects of an intranasal administration of oxytocin (OT) to parents of children with autism spectrum disorders (ASD) on the quality of mother-father-child interactions. Physiological and behavioral measures of parent-child triadic interaction quality will be assessed. H1: Parents who receive OT will demonstrate greater parental engagement and nonverbal prosocial behaviors compared to parents who receive placebo. H2: Children with ASD whose parents receive OT will have increased nonverbal prosocial behaviors during the discussion and play tasks compared to children whose parents' receive placebo. H3: Parents who receive OT will demonstrate increased behavioral and physiological synchrony with their child during the discussion and play tasks compared to parents who receive placebo and their child.
Key facts
- Study ID
- NCT01912378
- Run by
- University of California, San Francisco
- People needed
- 0
- Starts
- 2013-08-01
- Expected to finish
- 2015-05-01
- Last updated by the study team
- 2019-01-16
Who can join
Age: 7 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- For parents of patients with ASD and TD controls:
- Age between 25 and 60 years old
- Live with child
- Read and communicate in English
- For patient with ASD:
- Age between 7 and 12 years old
- Lives with parents
- Has diagnosis of autism spectrum disorder, pervasive developmental disorder, or pervasive developmental disorder-not otherwise specified(PDD-NOS)
- Communicates in English
- Has IQ at or above 75
- For TD controls:
- Age between 7 and 12 years
- Lives with parents
You may not qualify if…
- For parents of patients with ASD and TD controls:
- Female parents who state they are pregnant or have a positive pregnancy test
- Severe psychiatric, neurologic or medical illness
- Severe nasal pathology, atrophic rhinitis, recurrent nose bleeds, or history of cranial-surgical procedures (hypophysectomy)
- History of severe psychiatric diagnosis including schizophrenia, bipolar, and autism
- Divorce or separation
- Hypertension, pacemaker, cardiovascular medications
- For patients with ASD:
- IQ lower than 75
- For TD controls:
- Current psychiatric illness or developmental disability
- Current psychiatric medication
Where it is running
- University of California, San Francisco — San Francisco, California, United States
Full record on ClinicalTrials.gov
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