Immune Response in Celiac Disease on In-vitro Gluten Challenge

Completed

Conditions studied: Celiac Disease

In brief

The main purpose of this study is to see how cells taken from the lining of the intestine behave in the laboratory with exposure to gluten and other substances that act on the immune system. The cells lining the intestine of a person with celiac disease should be different than a person without celiac disease. The study doctors would like to see how the cells react after coming in contact with gluten and if substances that act on the immune system can prevent gluten related inflammation. Examples of these substances include steroids. The cells should produce chemicals of their own in response to the gluten. These other chemicals will be measured and the results compared between those with: * celiac disease that does not respond to a gluten-free diet (refractory celiac disease) * celiac disease which is controlled by a gluten-free diet * uncontrolled celiac disease (either newly diagnosed with celiac disease or not on a gluten-free diet * gluten-sensitivity * disorders other than celiac disease.

Key facts

Study ID

NCT01909050

Run by

Beth Israel Deaconess Medical Center

People needed

42

Starts

2013-02-01

Expected to finish

2018-03-01

Last updated by the study team

2018-03-19

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18-75 years of age
• Undergoing a clinically indicated upper endoscopy

You may not qualify if…

• Anticoagulation or antiplatelet therapy
• Known active non-celiac intestinal inflammatory disorder

Where it is running

• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.