Beraprost-314d Added-on to Tyvaso® (BEAT)

Completed · Phase 3 · Has a placebo group

Conditions studied: Pulmonary Arterial Hypertension

In brief

This is a multicenter, double-blind, randomized, placebo-controlled Phase 3 study, to assess the efficacy and safety of BPS-314d-MR when added-on to inhaled treprostinil (Tyvaso®)in patients with pulmonary arterial hypertension. Patients new to Tyvaso, will enter a run-in period on inhaled treprostinil until 90 days of experience is achieved to ensure drug tolerability before enrolling in the study. Treatment groups consist of one active and one placebo group. Subjects will be randomly allocated in a 1:1 ratio to one of the two treatment groups.

Key facts

Study ID

NCT01908699

Run by

Lung Biotechnology PBC

People needed

273

Starts

2013-05-31

Expected to finish

2019-02-19

Last updated by the study team

2020-08-03

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The following are inclusion criteria to be enrolled in this study:
• Male or female, age 18 to 80 years (inclusive).
• Established diagnosis of pulmonary arterial hypertension that is either idiopathic or familial PAH, collagen vascular disease associated PAH, PAH associated with HIV infection, PAH induced by anorexigens/toxins, or PAH associated with repaired congenital systemic-to-pulmonary shunts (repaired ≥1 years).
• If HIV positive, has a CD4 lymphocyte count ≥200 cells/mm3 within 30 days of Baseline Visit and is receiving current standard of care antiretroviral or other effective medication.
• At the Screening Visit, WHO functional class III or IV and who have declining or unsatisfactory clinical response to current PAH therapy.
• At the Baseline Visit, WHO functional class III or IV and who have declining or unsatisfactory clinical response to inhaled treprostinil therapy.
• Able to walk unassisted (oxygen use allowed).
• A 6-Minute Walk distance (6MWD) of ≥ 100 meters at the Screening Visit.
• Previous (within five years prior to the Baseline Visit) right heart cardiac catheterization (RHC) with findings consistent with PAH, specifically mean Pulmonary Arterial Pressure (PAPm) ≥25 mmHg (at rest), Pulmonary Capillary Wedge Pressure (PCWP) (or left ventricular end diastolic pressure) ≤15 mmHg, and Pulmonary Vascular Resistance (PVR) >3 mmHg/L/min.
• Echocardiography excluding any clinically significant left heart disease (e.g. left sided valve disease, wall motion abnormality suggesting of myocardial infarction, left ventricular hypertrophy, etc).
• Pulmonary function tests conducted within 12 months before or during the Screening period to confirm the following:
• Total lung capacity (TLC) is at least 60% (predicted value) and
• Forced expiratory volume at one second (FEV1) of at least 50% (predicted value).
• Subjects receiving additional FDA approved PAH therapies must be stable on their current dose for at least 30 days prior to the Baseline Visit, apart from modification of anticoagulant or diuretic dosages.
• Must have completed 90 days of uninterrupted inhaled treprostinil treatment and received a stable dose of inhaled treprostinil for at least 30 days prior to Baseline to be eligible for randomization into the study.
• Women of child-bearing potential (defined as less than 1 year post-menopausal and not surgically sterile) must be practicing abstinence or using two highly effective methods of contraception (defined as a method of birth control that result in a low failure rate, i.e., less than 1% per year, such as approved hormonal contraceptives, barrier methods [such as a condom or diaphragm] used with a spermicide, or an intrauterine device). Subject must have a negative pregnancy test at the Screening and Baseline Visits.
• Willing and able to comply with study requirements and restrictions.

You may not qualify if…

• Patients who meet any of the following criteria will be excluded from the study:
• Pregnant or lactating.
• Has previous experience with beraprost or BPS-314d (i.e., BPS-IR, BPS-MR or BPS-314d- MR).
• PAH related to any condition not covered under inclusion criteria, including but not limited to pulmonary venous hypertension, pulmonary veno-occlusive disease, pulmonary capillary hemangiomatosis, or chronic thromboembolic pulmonary hypertension.
• History of interstitial lung disease, unless subject has collagen vascular disease and has had pulmonary function testing conducted within 12 months of the Baseline Visit demonstrating a total lung capacity ≥60% of predicted.
• Has active hemorrhagic condition (e.g., upper digestive tract hemorrhage, hemoptysis, etc), or has a pre-existing condition that, in the Investigator's judgment, may increase the risk for developing hemorrhage during the study (e.g., hemophilia). Transient hemorrhage (e.g., epistaxis, normal menstrual bleeding, gingival bleeding, hemorrhoidal bleeding, etc) will not preclude enrollment.
• Has received any investigational drug, device or therapy within 30 days prior to the Baseline Visit or is scheduled to receive another investigational drug, device or therapy during the course of the study.
• Has any musculoskeletal disease or any other disease that would significantly limit ambulation.
• Has any form of unrepaired or recently repaired (< 1 year) congenital systemic-to-pulmonary shunt other than patent foramen ovale.
• Evidence of significant coronary arterial disease with symptoms, such as angina.
• Left sided myocardial disease as evidenced by left ventricular ejection fraction < 40%, or shortening fraction <22%.
• Has creatinine clearance <30 (using the Cockroft-Gault formula) or requires hemodialysis.
• Has Childs-Pugh class C liver cirrhosis.
• Has had previous atrial septostomy.
• Any other clinically significant illness or abnormal laboratory values (measured during the Screening period) that, in the opinion of the Investigator, might put the subject at risk of harm during the study or might adversely affect the interpretation of the study data.
• Anticipated survival less than 1 year due to concomitant disease.
• The Sponsor recognizes that the pulmonary hypertension population is complex and diverse. In order to facilitate enrollment of appropriate subjects to this pivotal trial, Investigators are strongly encouraged to contact the medical director or study team to discuss potential study subjects who have comorbid conditions before enrollment into this study. See Appendix 9 for additional details.
• No waivers to entry criteria are allowable in this study. Subjects who are initially ineligible for this study may be reassessed for eligibility after consultation with the Sponsor.

Where it is running

• Cedars-Sinai Medical Center Heart Institute — Beverly Hills, California, United States
• Allianz Research Institute Inc. — Fountain Valley, California, United States
• University of California San Francisco - Fresno — Fresno, California, United States
• University of California - San Diego — La Jolla, California, United States
• University of California Los Angeles — Los Angeles, California, United States
• Keck Medical Center of USC — Los Angeles, California, United States
• Veterans Affairs Greater Los Angeles Healthcare System — Los Angeles, California, United States
• Center for Advanced Pulmonary Medicine — Rancho Mirage, California, United States
• University of California - San Francisco — San Francisco, California, United States
• Cottage Pulmonary Hypertension Center — Santa Barbara, California, United States
• Stanford University — Stanford, California, United States
• Harbor-UCLA Medical Center — Torrance, California, United States
• University of Colorado Denver — Aurora, Colorado, United States
• Aurora Denver Cardiology Associates — Denver, Colorado, United States
• South Denver Cardiology Associates P.C. — Littleton, Colorado, United States
• Yale School of Medicine — New Haven, Connecticut, United States
• Bay Area Cardiology Associates, P.A. — Brandon, Florida, United States
• Florida Lung, Asthma, and Sleep Institute — Celebration, Florida, United States
• University of Florida — Gainesville, Florida, United States
• University of Florida College of Medicine — Jacksonville, Florida, United States
• Mayo Clinic — Jacksonville, Florida, United States
• Florida Hospital — Orlando, Florida, United States
• Orlando Health Heart Institute — Orlando, Florida, United States
• South Miami Heart Specialists — South Miami, Florida, United States
• University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.