Viral Testing and Biomarkers to Reduce Antibiotic Use for Respiratory Infections

Completed · Not applicable

Conditions studied: Respiratory Infections

In brief

This trial is a pilot study to determine the feasibility of a randomized clinical trial comparing a treatment algorithm consisting of a limited number of clinical parameters, rapid molecular viral diagnostics, and serum procalcitonin testing to standard of care for directing antibiotic use in patients with non-pneumonic lower respiratory tract infection. The reduction in antibiotic use in those subjects randomized to the treatment algorithm compared to those randomized to standard care will be determined.

Key facts

Study ID

NCT01907659

Run by

University of Rochester

People needed

300

Starts

2013-10-01

Expected to finish

2014-06-01

Last updated by the study team

2014-07-02

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Hospitalized with symptoms of a respiratory infection
• Age > 21 years
• Systolic Blood Pressure > 90mm Hg
• Patient or health care designee can provide written informed consent

You may not qualify if…

• Intensive Care Requirement
• Antibiotics received prior to admission
• More than 24 hours of antibiotics received prior to enrollment
• Active chemotherapy or pulmonary radiation therapy
• Immunosuppressive conditions
• Conditions know to increase PCT values
• Definite infiltrate on CXR •% of band forms in peripheral blood > 15

Where it is running

• Rochester General Hospital — Rochester, New York, United States

Full record on ClinicalTrials.gov

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