Prevention Trial of Family Focused Treatment in Youth at Risk for Psychosis

Completed · Not applicable

Conditions studied: Psychosis

In brief

Preventing psychotic disorders such as schizophrenia and associated functional disability could relieve an enormous burden of personal and family suffering and economic losses to society. This project aims to conduct a pilot randomized trial to determine the efficacy of a family-focused treatment in comparison with treatment-as-usual in enhancing functional outcomes, stabilizing symptoms, and preventing or delaying the onset of full psychosis in transitional age youth with prodromal symptoms. The results of this study will be crucial for the development of cost-effective, evidence-based psychosocial approaches to psychosis prevention and thus will have major implications for public health.

Key facts

Study ID

NCT01907282

Run by

University of California, Los Angeles

People needed

129

Starts

2010-01-01

Expected to finish

2013-01-01

Last updated by the study team

2013-07-24

Who can join

Age: 12 and older, up to 35. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 12 years, 0 months and 35 years, 11 months
• Speaks and writes English
• Availability of at least one family member for treatment
• Meets criteria for one of three prodromal syndromes as assessed by the
• Structured Interview for Prodromal Syndromes:
• attenuated positive symptoms that are sub-psychotic in duration and intensity and have begun or worsened in the past year;
• brief intermittent psychosis, defined as or syndromal psychotic symptoms that are have been present intermittently with onset in the previous 3 months; or
• genetic risk and deterioration, defined as a diagnosis of schizotypal personality disorder or having a first degree relative with a psychotic disorder, plus having experienced a substantial decline (30% or greater) in Global Assessment of Functioning scores in the last year.

You may not qualify if…

• Diagnosis of schizophrenia or schizoaffective disorder
• Pervasive developmental disorders
• Current substance or alcohol dependence
• Neurological disorders

Where it is running

• UCLA School of Medicine — Los Angeles, California, United States
• University of California, San Diego — San Diego, California, United States
• Yale University — New Haven, Connecticut, United States
• Emory University — Atlanta, Georgia, United States
• Harvard University/Beth Israel Deconess Medical Center — Boston, Massachusetts, United States
• Zucker Hillside Hospital — New York, New York, United States
• University of North Carolina — Chapel Hill, North Carolina, United States
• University of Calgary — Calgary, Alberta, Canada

Full record on ClinicalTrials.gov

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