Plasma and Urine TMAO Formation and Changes to Oxidized LDL After Ingestion of Different Amounts of Egg

Completed · Not applicable

Conditions studied: Biomarkers of Cardiovascular Disease

In brief

Eggs contain an essential nutrient called choline and adequate levels of choline are required for good health. Studies in mice have demonstrated that high levels of choline may increase risk of heart disease through a process that involves the breakdown of choline by gut bacteria. Previous research did not show that human consumption of eggs increases risk of heart disease. This study is designed to investigate whether the number of eggs in the diet affects blood and urine markers for heart disease.

Key facts

Study ID

NCT01906554

Run by

University of North Carolina, Chapel Hill

People needed

6

Starts

2012-10-01

Expected to finish

2013-07-01

Last updated by the study team

2013-07-24

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy
• non-smoker
• Body mass index between 20 to 39 kg/m²

You may not qualify if…

• History of chronic system disease/s (e.g., hepatic, renal, cardiovascular, intestinal)
• Diabetes controlled by insulin
• Alcohol or illegal drug misuse/abuse
• Use of antibiotics or choline-containing supplements within three months of study
• Allergies to soy, eggs, wheat or other food
• Use of drugs or medications known to alter liver metabolism, cardiovascular and/or kidney function
• Abnormal physical examination or abnormal clinical laboratory values
• Pregnancy
• Unusual dietary habits

Where it is running

• University of North Carolina at Chapel Hill Nutrition Research Institute — Kannapolis, North Carolina, United States

Full record on ClinicalTrials.gov

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