Development of Novel Therapies for NIDDM

Completed · Not applicable

Conditions studied: Metabolism

In brief

The overarching goal of this program project grant is the development of technologies that lead to new methods for studying, detecting, and treating type 2 diabetes, and their integration with hypothesis-driven diabetes research projects. Project 4 of the grant, led by Dr. Craig Malloy at UTSW, will develop and apply new technology in MRI to test core hypotheses about the development of insulin resistance in people. The long-term goal is to develop technology to monitor metabolism in skeletal muscle, brain and the liver using magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) in a 3 Tesla and 7 Tesla MRI scanners. These advanced imaging methods allow researchers to take pictures of the inside of the body and to measure metabolism as it occurs in the MRI scanner. Standard clinical MRI for medical diagnosis and treatment is performed in a 1 Tesla or 3 Tesla MRI scanner. A primary goal of the 7 Tesla research program is to develop a group of protocols for investigating specific metabolic pathways in adipose (fat) tissue, skeletal muscle and the liver. This study is being done to improve methods of imaging and measuring molecules in a 3 Tesla or 7 Tesla scanners.

Key facts

Study ID

NCT01905722

Run by

Duke University

People needed

64

Starts

2013-12-10

Expected to finish

2017-05-17

Last updated by the study team

2019-05-31

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Good general health (normal vital signs; no acute signs or symptoms of illness)
• Able to give informed consent
• Able to tolerate study procedures including insertion of an intravenous catheter and approximately 90 minutes in the MRI scanner
• Aim 3 phase subjects will have BMI of 28 to 35 and a sedentary lifestyle; may be pre-diabetic or have undiagnosed type 2 diabetes

You may not qualify if…

• Known diagnosed disease, including known heart rhythm disturbance, cancer or risk of seizure disorder or other disorder that could create risk to the subject
• Pregnancy
• Subjects with implanted metal that would compromise safety in MR use
• Subjects not fluent in English will be excluded because the immediate ability to respond to instructions in the scanner is required

Where it is running

• University of Texas Southwestern Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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