The Role of S-nitrosohemoglobin in Regulating Systemic Blood Flow During Hypoxia and Normoxia

Stopped early · Early Phase 1

Conditions studied: Focus is Determination of the Role of SNO-Hb in Forearm Blood Flow Regulation

In brief

Nitric oxide is believed to contribute to regulation of blood flow by its selective binding to circulating hemoglobin (forming S-nitrosohemoglobin, SNO-Hb) and release in a PO2-dependent manner. This study is designed to test that hypothesis by measuring the effect of hypoxia and exercise on forearm blood flow before and after depletion of SNO-Hb using oral N-acetylcysteine.

Key facts

Study ID

NCT01905696

Run by

Duke University

People needed

10

Starts

2013-03-01

Expected to finish

2013-08-01

Last updated by the study team

2016-12-29

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy volunteers

You may not qualify if…

• Pregnancy
• smoking
• pulmonary disease
• cardiovascular disease

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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