Moderate Intensity Exercise and Phenylketonuria

Stopped early · Not applicable

Conditions studied: Phenylketonuria, PKU

In brief

Phenylketonuria (PKU), an inherited genetic disorder, can cause irreversible brain damage, declined executive function, and autistic tendencies unless a phenylalanine (Phe) restricted diet is consistently maintained throughout life. Promoting anabolism, the uptake of free amino acids from the extracellular space, is a key component to maintaining plasma phenylalanine concentrations within treatment range among patients with PKU. Exercise promotes muscle protein synthesis and anabolism, but the effect on blood phenylalanine concentrations in patients with PKU has not been reported. Our objective is to assess the impact of an acute bout of moderate intensity exercise on protein oxidation and plasma amino acid concentrations, as a potential adjunctive therapy for patients with PKU. The investigators hypothesize that moderate intensity exercise decreases amino acid oxidation, increases muscle protein synthesis, and promotes tissue uptake of essential amino acids, thereby lowering plasma phenylalanine concentrations in patients with Phenylketonuria.

Key facts

Study ID

NCT01904708

Run by

Oregon Health and Science University

People needed

2

Starts

2013-05-01

Expected to finish

2014-06-01

Last updated by the study team

2014-10-16

Who can join

Age: 14 and older, up to 17. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• plasma phenylalanine concentration of >1200 micromols at diagnosis
• treated by dietary phenylalanine restriction from early infancy
• willing to participate in this study
• stable BMI of 20-25 for the past 3 months
• currently in average to good physical fitness condition
• physically active 3-4 days per week

You may not qualify if…

• previously or are currently taking approved or experimental pharmacologic treatments (i.e.: Biopterin (BH4), sapropterin dihydrochloride (Kuvan), Large Neutral Amino Acids (LNAA), pegylated phenylalanine ammonia lyase (PEG-PAL))
• recent history of weight loss
• endocrine disorder
• pregnant
• anemic
• involved in any other study or research protocol
• participation in a current strength training or performance training regimen

Where it is running

• Oregon Health and Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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