Chemoimmunotherapy and Radiation in Pancreatic Cancer
Completed · Phase 1
Conditions studied: Locally Advanced Malignant Neoplasm
In brief
The goal of this study is to evaluate the safety of combination treatment that includes chemotherapy, radiation therapy, and immunotherapy in patients with pancreatic cancer.
Key facts
- Study ID
- NCT01903083
- Run by
- Providence Health & Services
- People needed
- 10
- Starts
- 2013-07-01
- Expected to finish
- 2017-12-01
- Last updated by the study team
- 2018-02-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Pancreatic adenocarcinoma
- Locally advanced unresectable disease, or borderline resectable disease
- ECOG (Eastern Cooperative Oncology Group)Performance Status 0 or 1
- Ability to provide consent and comply with study protocol
- Women of child-bearing potential must have a negative pregnancy test and avoid pregnancy during the study
You may not qualify if…
- Age < 18
- History of other malignancy in previous 2 years except carcinoma in situ of the cervix or bladder, or non-melanoma skin cancer
- Previous chemotherapy or radiation therapy for pancreatic cancer or previous radiation to the target field
- Clinically active autoimmune disease or active infection
- History of heart attack within 90 days or stroke within 6 months, hypertension requiring change in blood pressure medications in the last 4 weeks, hypotension, uncontrolled arrhythmias, heart failure (NYHA >= Class 2 in last 6 months), unstable angina, or angina during sexual activity
- Use of nitrates or nitroglycerin
- History of hereditary degenerative retinal disorders including retinitis pigmentosa
- Chronic systemic corticosteroid use at supra-physiologic doses
- Use of recreational drugs called 'poppers' like amyl nitrite and butyl nitrite
- Blood test results (neutrophils < 1000 /uL (microliter); hemoglobin < 9 gm /dL; platelet count < 1000 cells / uL; significant coagulopathy; significant liver or renal dysfunction
Where it is running
- Portland Providence Medical Center — Portland, Oregon, United States
Full record on ClinicalTrials.gov
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