Protective Effects of Propranolol in Adults

Stopped early · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Burn

In brief

This efficacy and safety trial will examine the effects and safety of propranolol administered to adult patients with severe burn injury. The investigators hypothesize that propranolol will provide significant benefit to adults following severe burn injury at doses that are safe and do not increase risk of adverse infectious and non-infectious outcomes.

Key facts

Study ID

NCT01902810

Run by

The University of Texas Medical Branch, Galveston

People needed

47

Starts

2013-07-01

Expected to finish

2019-07-12

Last updated by the study team

2019-11-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ≥ 20% Total Body Surface Area (TBSA) burn with anticipated operation need on admission
• Age ≥ 18 years
• Admission within 72 hours of injury

You may not qualify if…

• Age <18
• Patients unlikely to survive injury or with ;age = total burn size ≥ 130
• Electrical or deep chemical burn
• Malignancy currently undergoing treatment or history of cancer treatment within 5 years
• History of HIV or AIDS
• Presence of anoxic brain injury that is not expected to result in complete recovery
• Currently treated for Chronic Obstructive Pulmonary Disease (COPD), asthma or other chronic pulmonary conditions
• History of Congestive Heart Failure (CHF) (ejection fraction < 20%)
• Pre-injury medications including blocking agents (alpha or beta) or other anti-arrhythmic drugs
• Pregnant women
• Prisoners
• History of cardiac arrhythmia requiring medication
• Medical condition requiring glucocorticoid treatment
• Patients with concurrent conditions that in the opinion of the investigator may compromise patient safety or study objectives

Where it is running

• University of Florida — Gainesville, Florida, United States
• Loyola University Burn Center — Maywood, Illinois, United States
• University of Iowa — Iowa City, Iowa, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Cornell Burn Center — New York, New York, United States
• Ohio State University — Columbus, Ohio, United States
• University of Texas, Southwestern — Dallas, Texas, United States
• University of Texas Medical Branch — Galveston, Texas, United States
• University of Washington — Seattle, Washington, United States
• University of Toronto — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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