Efficacy of Intravenous Ibuprofen Compared to Intravenous Ketorolac for Pain Control Following Arthroscopic Knee Surgery
Completed · Phase 4
Conditions studied: Pain
In brief
The purpose of this study is to assess the efficacy of intravenous ibuprofen compared to ketorolac for the treatment of postoperative pain as measured by patient pain intensity (Visual Analog Scale, VAS)
Key facts
- Study ID
- NCT01901393
- Run by
- Cumberland Pharmaceuticals
- People needed
- 100
- Starts
- 2013-07-01
- Expected to finish
- 2014-08-01
- Last updated by the study team
- 2016-03-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients scheduled for knee arthroscopy
You may not qualify if…
- Inadequate IV access.
- History of allergy or hypersensitivity to any component of ibuprofen, ketorolac, aspirin (or aspirin related products), non-steroidal anti-inflammatory drugs (NSAIDs), opioids or cyclooxygenase-2 (COX-2) inhibitors.
- Less than 18 years of age.
- Use of analgesics less than 8 hours prior to surgery.
- Patients with active, clinically significant anemia.
- History or evidence of asthma or heart failure.
- Pregnant.
- Recent history of chronic opioid use.
- Concomitant use of probenecid.
- Inability to understand the requirements of the study, be willing to provide written informed consent (as evidenced by signature on an informed consent document approved by an Institutional Review Board [IRB]), and agree to abide by the study restrictions and to return for the required assessments.
- Refusal to provide written authorization for use and disclosure of protected health information.
Where it is running
- Shrock Orthopedic Research — Fort Lauderdale, Florida, United States
- Rush University Medical Center — Chicago, Illinois, United States
- North Mississippi Sports Medicine & Orthopaedic Clinic — Tupelo, Mississippi, United States
- The Ohio State University Vexner Medical Center — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
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