Electrical Impedance Myography: Natural History Studies inNeuromuscular Disorders and Healthy Volunteers

Recruiting now · Not applicable

Conditions studied: Neuromuscular Disease, Motor Neuron Disease, Inherited Neuromuscular Conditions, Inherited Neuropathies

In brief

Background: \- Electrical impedance myography (EIM) is a new technique being studied to see if it is helpful in evaluating muscle disorders and nerve disorders. EIM looks at how a mild, painless electrical current travels through muscles. Researchers want to gain experience in using the EIM device. They will collect information on the results of using it on people with and without nerve and muscle diseases, and compare that with information from other standard tests. First, they will test the device on healthy people. Then they will test people with a variety of neuromuscular diseases. Because the test is noninvasive and not painful, researchers will test both children and adults. Objectives: \- To gain experience using the EIM muscle testing device. Eligibility: * Healthy volunteers at least 2 years old. * Individuals at least 2 years old who have neuromuscular disease. Design: * Participants will be screened with a medical history and physical exam. * Participants will have one 2-3 hour clinic visit. Researchers may request follow-up visits. * Participants will be tested with the EIM device. The device and small electrodes will be placed on their skin. An electric current will pass through the device, but the participants will not feel this. * Participants may have an ultrasound test. A gel will be put on their skin, and a device will be moved over the skin. * Participants may have a nerve test. Electrodes will be placed on their skin, and they will feel a small shock. * Participants may have a test where a thin needle is inserted in their muscle.

Key facts

Study ID

NCT01900132

Run by

National Institute of Neurological Disorders and Stroke (NINDS)

People needed

275

Starts

2013-06-20

Expected to finish

2027-06-01

Last updated by the study team

2026-08-04

Who can join

Age: 2 and older, up to 110. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Suspected motor neuron disease or
• Suspected myopathy or
• Suspected neuropathy or
• Suspected movement disorders that impair intracortical processes
• Age of 2 years or older
• Ability of subject to sign a written informed consent document.
• NIH EMPLOYEES:
• NIH employees and staff may participate, however EMG Section, OCD, NINDS, employees may not participate.

You may not qualify if…

• HEALTHY VOLUNTEERS-ADULTS
• Medical conditions that require medications that affects the physiological measures being tested. Some conditions that may be excluded are diabetes, kidney and liver disease.
• History of stroke, muscle disorders, peripheral neuropathy or spine surgery
• HEALTHY VOLUNTEERS-PEDIATRIC
• Medical conditions that require medications that affects the physiological measures being tested. Some conditions that may be excluded are diabetes, kidney and liver disease.
• History of stroke, muscle disorders, peripheral neuropathy or spine surgery
• SUBJECTS WITH NEUROMUSCULAR DISEASE:
• No clinical evidence of a neuromuscular disorder on clinical evaluation.

Where it is running

• National Institutes of Health Clinical Center — Bethesda, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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