Mechanisms and Functional Outcomes of Exercise Progression Models in the Elderly

Completed · Not applicable

Conditions studied: Elderly, Sedentary

In brief

The aim of this study is to devise a sufficiently high intensity training program that provided an optimal stimulus to remove the peripheral factors known to reduce functional capacity, and can be cardiovascular and orthopedically well tolerated by the elderly. Findings from study laboratories have suggested that a regional specific training stimulus (RSTS) results in rapid improvements in both vascular and muscular function. RSTS is a novel combination of resistance training and aerobic training applied simultaneously, and in a serial manner, to specific regions of the body. It involves high-intensity and frequency muscle contractions, generating a targeted exercise stimulus, without producing excessive cardiovascular or orthopedic stress. The hypothesis is that initiating training with RSTS at multiple, strategically selected peripheral sites, in a serial manner will elicit local vascular and muscular changes, thereby preparing individuals at elevated risk of losing independence, to respond and progress more favorably to whole-body exercise.

Key facts

Study ID

NCT01899586

Run by

Duke University

People needed

108

Starts

2009-09-01

Expected to finish

2011-11-01

Last updated by the study team

2014-03-04

Who can join

Age: 70 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• >70 yrs of age
• Sedentary (exercising <1 day/wk)
• Non-smokers
• Able to ambulate without use of an assistive device
• Able to walk between 200-450m on a 6-minute walk test

You may not qualify if…

• Oxygen dependent
• Recent medications changes (within 3 months)
• Current Smokers
• Fixed-rate pacemakers
• Uncontrolled hypertension or Type II diabetes
• Positive ECG changes or angina during CPX testing
• Unable to complete a maximal CPX to volitional fatigue
• AHA Class D, or NYHA Class III or IV heart failure

Where it is running

• Pennington Biomedical Center — Baton Rouge, Louisiana, United States
• Duke Center for Living; Wallace Clinic — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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