Stimulation of Diet-Induced Thermogenesis by Cold-Exposure

Completed · Not applicable

Conditions studied: Thermogenesis, Brown Adipose Tissue

In brief

Human fat tissue is essentially white fat, the main function of which is to store excess energy intake, and to release it when necessary. Brown fat is far less abundant and is present in the body to burn fat (and thus energy) to generate heat to maintain body temperature around 96 degrees. This phenomenon is called thermogenesis. When humans are exposed to cold on a chronic basis, brown fat expands and becomes more active, and consequently burns more energy. The amount of brown fat is higher during winter, and daily short (20 minutes) exposures to cold might be sufficient to induce its activity. We hypothesized that daily short term (20 minutes) exposure to a cold environment (4 °C) for four weeks increases adaptive BAT-mediated thermogenesis. CIT and DIT will be increased proportionally (the increase in CIT and DIT will be correlated).

Key facts

Study ID

NCT01898949

Run by

Pennington Biomedical Research Center

People needed

9

Starts

2010-11-01

Expected to finish

2012-05-01

Last updated by the study team

2016-01-08

Who can join

Age: 18 and older, up to 35. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Men between the ages of 18-35 years, inclusive
• Body mass index (BMI) between 18.5 and 25.0 kg/m2, inclusive, with a stable weight (<2kg variation) within the past 3-6 months
• Non smokers
• On no medication or recreational drugs
• Healthy as assessed by a standard self-reported screening health questionnaire
• Provide written informed consent

You may not qualify if…

• Smokers
• Individuals taking any medications
• Individuals taking any stimulants
• Individuals taking beta-blockers
• Individuals with diabetes or impaired fasting glucose as defined by theADA criteria, i.e. fasting plasma glucose concentration ≥ 5.6 mmol/L (100 mg/dl).
• Individuals with chronic alcohol consumption (> 3 drinks per day) or drug abuse
• Individuals unable to abstain from caffeinated beverage or alcohol the days of study
• Individuals with pacemakers or defibrillators
• Individuals with history of heart disease or history of stroke
• Individuals having a significant recent loss or gain of weight
• Individuals involved in regular (> 3 times per week), intense competitive sporting activities.
• Individuals involved in intensive exercise activity.

Where it is running

• Pennington Biomedical Research Center — Baton Rouge, Louisiana, United States

Full record on ClinicalTrials.gov

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