Combined Treatment of Arterial Hypertension and Atrial Fibrillation
Completed · Phase 2
Conditions studied: Arterial Hypertension, Atrial Fibrillation
In brief
The purpose of this study is the comparative evaluation of systolic blood pressure (SBP) lowering, atrial fibrillation (AF) recurrence and clinical data in patients with paroxysmal/persistent AF and resistant/non-resistant hypertension, undergoing AF ablation alone or combined with percutaneous renal denervation.
Key facts
- Study ID
- NCT01897545
- Run by
- Meshalkin Research Institute of Pathology of Circulation
- People needed
- 60
- Starts
- 2012-04-01
- Expected to finish
- 2013-06-01
- Last updated by the study team
- 2013-10-09
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Symptomatic drug-refractory AF (with history of failure of ≥2 class I or III antiarrhythmic drugs) in patients referred for catheter ablation of AF
- PAF with ≥1 monthly episodes or PersAF in patients who had already undergone ≥3 electrical cardioversions. PAF was defined as episodes lasting less than 7 days with spontaneous termination. PersAF was defined as lasting more than 7 days before being terminated pharmacologically or by electrical cardioversion.
- Office-based systolic blood pressure of ≥140/90 mm Hg, despite treatment with 3 antihypertensive drugs (including 1 diuretic)
- A glomerular filtration rate ≥45 mL/min/1⋅73 m2, with modification of diet using a renal disease formula
You may not qualify if…
- Secondary causes of hypertension
- Severe renal artery stenosis or dual renal arteries
- Congestive heart failure with NYHA II-IV symptoms
- Left ventricular ejection fraction <35%
- Transverse left atrial diameter > 60 mm on transthoracic echocardiography
- Previous AF ablation procedure
- Treatment with amiodarone
- Previous renal artery stenting or angioplasty
- Type 1 diabetes mellitus
Where it is running
- The Valley Health System — New York, New York, United States
- Athens Euroclinic — Athens, Greece
- State Research Institute of Circulation Pathology — Novosibirsk, Russia
Full record on ClinicalTrials.gov
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