Metabolic Actions of Omega-3 Fatty Acids

Completed · Not applicable · Has a placebo group

Conditions studied: Metabolic Syndrome

In brief

The metabolic syndrome raises the risk of heart disease and is currently at epidemic proportions in the U.S. It consists of 3 of the following components: central obesity, high triglycerides, low HDL, abnormal blood pressure and impaired fasting glucose levels. Previous studies have suggested that omega-3 fish oil may influence some of these components but the mechanisms involved are not well understood. Therefore, this proposal will investigate how omega-3 fish oils affect inflammation, lipids and fat breakdown by comparing it to placebo. Favorable outcomes from this study could translate into a new approach to improve heart disease risk in men and women with the metabolic syndrome.

Key facts

Study ID

NCT01896414

Run by

University of Maryland, Baltimore

People needed

40

Starts

2014-07-01

Expected to finish

2016-05-30

Last updated by the study team

2020-01-14

Who can join

Age: 25 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Metabolic Syndrome, including 2 of the following:
• Treated Hyperlipidemia or Untreated Triglycerides > 150 mg/dL
• Waist circumference (inches) > 35 (women) or >40 (men)
• And at least 1 additional factor:
• Treated Hypertension or Untreated Blood pressure >130/85 and < 160/100 mm Hg
• HDL-C < 40 mg/dL men < 50 mg/dL women
• Glucose > 100mg/dL and HbA1c < 6.1%

You may not qualify if…

• Fasting TG > 500 mg/dL or LDL > 180 mg/dL
• Fasting glucose> 125 mg/dL or history of diabetes mellitus
• Hematologic or malignant disorders
• Morbid Obesity (BMI > 50 kg/m2)
• Endocrine (thyroid) or metabolic disorders (unless treated and under control)
• Alcohol consumption greater than (2) 4-ounce glasses of table wine, (2) 12-oz bottles of beer or 2 shots of spirits in men or women
• Active IV drug abuse within the past 6 months
• Clinical depression (per PI evaluation)
• Immunosuppressive or other therapy that would interfere with research testing

Where it is running

• University of Maryland Medical Center — Baltimore, Maryland, United States
• Amish Research Center — Lancaster, Pennsylvania, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.