Estrogen Therapy as Prevention in the Progression of Aneurysm (EPPA) Trial

Withdrawn before enrolling · Phase 2 · Has a placebo group

Conditions studied: Cerebral Aneurysm, Menopause, Treatment

In brief

This study aims to determine if hormone replacement therapy, given during perimenopause may prevent the progression of saccular cerebral aneurysms.

Key facts

Study ID

NCT01895881

Run by

Rush University Medical Center

People needed

0

Starts

2013-04-01

Expected to finish

2018-12-01

Last updated by the study team

2021-01-05

Who can join

Age: 40 and older, up to 52. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Generally healthy women, 40-52 years of age.
• At least one documented saccular intracranial cerebral aneurysm detected via catheter angiography, magnetic resonance angiography or computed tomography angiography.
• Clinical diagnosis of perimenopause, defined as regular or irregular menses with or without vasomotor symptoms.

You may not qualify if…

• Known or suspected estrogen-dependent neoplasia.
• Endometrial proliferation, hyperplasia, or malignancy at screening.
• Known hypersensitivity to estrogens, progestins.
• History of myocardial infarction, ischemic heart disease, lipid disorder, or congestive heart failure.
• Known or suspected pregnancy, or recent breast feeding (within 6 months).

Where it is running

• Rush University Medical Center — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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