Statin Therapy to Improve Medication Adherence

Completed · Phase 1

Conditions studied: Hypercholesterolemia, HMG COA Reductase Inhibitor Adverse Reaction

In brief

The purpose of this pilot study is to examine if using genetics can improve statin adherence in patients who should be taking statins but are not because of prior side effects with statins. This study will assist physicians in making a personalized health care plan for prevention of cardiovascular disease.

Key facts

Study ID

NCT01894217

Run by

Duke University

People needed

63

Starts

2011-05-01

Expected to finish

2014-04-01

Last updated by the study team

2015-01-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Current patient (defined as seen in the last year) of the Duke Primary Care at Pickett Road or Center for Living
• Age greater than or equal to 18 years
• Provider interested in prescribing statins for cardiovascular disease prevention
• Ability to provide informed consent

You may not qualify if…

• Prior rhabdomyolysis, defined as CK elevation > 10 times the upper limit of normal with any statin therapy
• Prior unexplained elevation in hepatic enzymes (AST or ALT > 3 times upper limit of normal) with any statin therapy
• Use of medications known to interfere with statin metabolism or disposition
• Participation in a drug research study in the past 30 days

Where it is running

• Duke Center for Living — Durham, North Carolina, United States
• Duke Primary Care Clinic at Pickett Road — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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